OUR RESEARCH
The Szeri lab focuses on understanding the complex molecular mechanisms of ectopic mineralization in rare hereditary disorders and multifactorial diseases.
Besides unraveling physiological processes leading to or inhibiting the calcification of soft tissues, we seek therapeutic approaches to prevent, alleviate, or resolve ectopic mineralization.
Plasma Inorganic Pyrophosphate Deficiency Links Multiparity to Cardiovascular Disease Risk
Front. Cell Dev. Biol., 09 December 2020
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP
Szeri F, Lundkvist S, Donnelly S, Engelke UFH, Rhee K, Williams CJ, Sundberg JP, Wevers RA, Tomlinson RE, Jansen RS, van de Wetering K.
PLoS Genet. 2020 Jul 8
Generation of fully functional fluorescent fusion proteins to gain insights into ABCC6 biology.
Szeri F, Niaziorimi F, Donnelly S, Orndorff J, van de Wetering K.
FEBS Lett. 2020 Oct 15.
RECENT MOST RELEVANT PUBLICATIONS
The mineralization regulator ANKH mediates cellular efflux of ATP, not pyrophosphate.
Szeri F, Niaziorimi F, Donnelly S, Fariha N, Tertyshnaia M, Patel D, Lundkvist S, van de Wetering K.
J Bone Miner Res. 2022 Feb 11. doi: 10.1002/jbmr.4528. Online ahead of print.
The pathogenic p.(R391G) ABCC6 displays incomplete penetrance implying the necessity of an interacting partner for the development of pseudoxanthoma elasticum
Szeri F, Miko A, Navasiolava N, Kaposi A, Verschuere S, Li Q, Terry SF, Boraldi F, Uitto J, van de Wetering K, Martin L, Quaglino D, Vanakker OM, Tory K, Aranyi T MedRxiv November 30, 2020
NEWS
Celebrating the thesis defense of Kamilla Országh & Ahmed Haji
Martin Várhegyi
obtained a Ph.D. fellowship at
Semmelweis University.
Congratulations!
Beatrix Molnár defended her MSc. Congratulations Trixi!
